Scale (coating), copper

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation / corrosion

Remarks:

other: prediction from hazard class

Type of information:

calculation (if not (Q)SAR)

Remarks:

Migrated phrase: estimated by calculation

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: No GLP but other quality assurance; software

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

other: software

Title:

Unnamed

Year:

2010

Materials and methods

Principles of method if other than guideline:

The potential of the UVCB substance to be corrosive, or skin irritant was established by classifying the complex metal substance based on Mixture rules from EU CLP (cut-off/ additivity of classified components to derive Hazard class). The classification criteria (as set out in EU CLP Guidance Annex I: 3.2.2.6 Corrosion and 3.2.2.7 Irritation) were used to estimate effects.

GLP compliance:

no

Remarks:

other quality assurance

Test material

Test material information

Constituent 1

Reference substance name:

Scale (coating), copper

EC Number:

273-744-9

EC Name:

Scale (coating), copper

Cas Number:

69012-45-9

IUPAC Name:

scale (coating), copper

Details on test material:

Typical and Worst Case across industry for Grade 1, 2, 3 and Grade 4 respectively as in IUCLID 1.2;
see IUCLID Section 1.4, for company specific elemental composition; and representative sample for mineralogical information (IUCLID Section 4.23 -Outotec report).

Results and discussion

Any other information on results incl. tables

The calculated classification via mixture toxicity rules resulted in "Skin corrosion/skin irritation: not classified”.

Applicant's summary and conclusion

Interpretation of results:

not irritating

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Result derived on basis of the Classification outcome (Mixture toxicity rules) from a Typical (across industry) as defined in IUCLID section 1.2/1.4/4.23 is "Skin corrosion/skin irritation: not classified".
The result is applicable to Grade 1, 2, 3 and Grade 4 Copper Scales that fall under the defined concentration ranges (IUCLID section 1.2).

Executive summary:

The study provided a conservative estimate of the Skin corrosion/skin irritant potential (not classified), derived on basis of the Classification outcome (Mixture toxicity rules) from a Typical (and max across industry) as defined in IUCLID section 1.2/1.4/4.23.

The result is applicable to Grade 1, 2, 3 and Grade 4 Copper scales that fall under the defined concentration ranges (IUCLID section 1.2).

The result is supported by (WoE) consideration from chemical & mineralogical information (IUCLID 4.23) showing that no significant amount of Skin irritant/corrosive could be detected in representative samples from both grades.

Water solubility test furthermore confirmed that the UVCB has low solubility, except for Si, Na, K, Ca and Cu where these constituents/species solubilised (at high loading of 5g/100ml and after ca. 14 -16 days) -with pH observed remaining at ca 9 or ca 7 (ie not exceeding to extremes >2 or >11,5).