Registration Dossier
Registration Dossier
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EC number: 273-744-9 | CAS number: 69012-45-9 By-product produced in the rolling of copper wire either in a conventional rod mill or a continuous cast rod mill. Consists of metallic copper, cuprous oxide and cupric oxide.
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- other: calculated from CLP software
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP but other quality assurance; software
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- other: software
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
- Principles of method if other than guideline:
- The UVCB substance as complex substance is classified regarding STOT-RE by applying rules for classification of mixtures (EU CLP guidance section 3.9.1 pg 365ff). The classification criteria (as set out in EU CLP Guidance Annex I: 3.9.2.9.7 pg 369) can be used to estimate effects derived from that classification/hazard.
- GLP compliance:
- no
- Remarks:
- other Quality assurance
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- max across industry for Grade 1 as defined in IUCLID section 1.2;
see IUCLID section 1.4 for company specific elemental composition, and representative sample for mineralogical information (IUCLID section 4.23 -outotec report).
Constituent 1
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The calculated classification via mixture toxicity rules resulted in “STOT-RE: not classified”.
Applicant's summary and conclusion
- Conclusions:
- result can be used to predict STOT-RE effect level and classify the UVCB substance.
- Executive summary:
The study provided a conservative estimate of the STOT-RE hazard, derived on basis of the Classification outcome (Mixture toxicity rules) from a typical and Worst case (max conc. on Ni, across industry) as defined in IUCLID section 1.2/1.4/4.23.
The result is applicable to Grade 1 and Grade 2 Copper scales that fall under the defined concentration ranges (IUCLID section 1.2).
The result is supported by (WoE) consideration from chemical & mineralogical information (IUCLID 4.23) showing that NO significant amount of STOT-RE Toxicant are present in representative samples or in max across industry (eg Ni species STOT Re cat 1 as Total Ni across industry below 1%; or Pb powder/compounds STOT-RE cat 2 species as Total Pb across industry is below 10% (ie in Grade 2, the Pb powder STOT Re cat 2 species are below 1%).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
