Registration Dossier
Registration Dossier
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EC number: 226-076-7 | CAS number: 5263-02-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: No data on materials and methods; the authors reference to a publication which is written in Russian language.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity and character of the effect of some zinc compounds
- Author:
- Shabalina LP and Spiridonova VS
- Year:
- 1 988
- Bibliographic source:
- Journal of hygiene, epidemiology, microbiology and immunology. Volume 32, issue 4, pages 397-405
Materials and methods
- Principles of method if other than guideline:
- Method is described in: "Problems of industrial toxicology, Editorial section of the managing department of the Secretariat of CMEA." Title: "Methodological instructions for the organization of studies for the substantiation of standards of harmful substances in the air of the working zone" (in Russian)
- GLP compliance:
- not specified
- Test type:
- other: unkown
Test material
- Reference substance name:
- 12539-71-8
- Cas Number:
- 12539-71-8
- IUPAC Name:
- 12539-71-8
- Details on test material:
- - Name of test material (as cited in study report): zinc carbonate basic monohydrate (2 ZnCO3 . 3Zn(OH)2 . H2O)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- no further data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 7 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: Mortality, body mass, summation-threshold index (STI) and rectal temperature
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Remarks on result:
- other: basic zinc carbonate monohydrate (tested in this study)
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 9 687 mg/kg bw
- Remarks on result:
- other: calculated for the anhydrous zinc carbonate, basic (see below)
Any other information on results incl. tables
Calculation:
According to the study report, the molecular weight of the substance tested (basic zinc carbonate monohydrate) is 576 g / mole. One molecule of water has a molecular weight of about 18 g / mole. Thus the anhydrous basic zinc carbonate has a molecular weight of 558 g / mole. Because 3,125 % tested substance of the high dose (10000 mg/kg) is actually water, the amount of anhydrous basic zinc carbonate test is 9687 mg/kg bw.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
