Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Approximately 20 years of cumulative experience in the production of synthetic amorphous aluminum sodium silicate (NAS) has not produced a single case of suspected contact allergy (Evonik 2009). NAS like synthetic amorphous silica is known to result in drying and possibly cracking of the skin. Following prolonged exposure, this was associated with eczematous skin changes.

The implementation of technical measures resulted in steady reduction of exposure over years. Furthermore, strict personal skin protection as well as skin care succeeded in almost eliminating any case of silicate-related skin irritation (Küppers and Ostendorf 2009, see Section 7.10.4).


Migrated from Short description of key information:
No experimental data in animals available. There is no evidence of skin sensitisation in exposed workers over about 20 years of practical experience.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:
Migrated from Short description of key information:
no data, no evidence after decades of experience from exposed workers.

Justification for classification or non-classification