Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 926-771-1 | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Materials and methods
Results and discussion
Any other information on results incl. tables
The long-term inhalation studies described in details in endpoint sections 7.5.3 and 7.7 show that FMMVF fibres induced minimal collagen deposition in the lungs of rats comparable to what is observed for any biologically inert dust at the same exposure levels. Furthermore, FMMVF fibres induce fibrosis, but no significant neoplastic changes in the lungs or in the pleura of rats. The mortality rate in the exposed animals was the same as for the control animals. From these studies it is concluded that FMMVF fibres have no acute toxicity by inhalation.
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Testing of acute inhalation toxicity is waived because results from long-term inhalation toxicity studies are available. These studies showed that inhalation of FMMVF fibres caused minimal collagen deposition and induced fibrosis, but no significant neoplastic changes in the lungs or pleura. The mortality rate in the exposed animals was the same as for the control animals. Based on these long-term inhalation studies FMMVF fibres are evaluated to have no acute toxicity by inhalation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
