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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Older study containing basic data but adequate for purpose.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1957
Report date:
1957

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
The study was conducted prior to development of the guideline, but is a standard acute oral toxicity study
GLP compliance:
no
Remarks:
: older study, pre-dates GLP
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl terephthalate
EC Number:
204-411-8
EC Name:
Dimethyl terephthalate
Cas Number:
120-61-6
Molecular formula:
C10H10O4
IUPAC Name:
dimethyl terephthalate
Details on test material:
No further details on test material.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
corn oil
Details on oral exposure:
The test material was administered as a 10% suspension in corn oil.
Doses:
The dose range was 200-3200 mg/kg bw.
No. of animals per sex per dose:
5 rats per dose level.
Control animals:
no
Details on study design:
The suspension in corn oil was administered orally. The rats were observed for 2 weeks after dosing. Bodyweights were recorded, and rats were observed for clinical signs and mortality.
Statistics:
No information available.

Results and discussion

Preliminary study:
No preliminary study conducted.
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 3 200 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No deaths
Mortality:
None.
Clinical signs:
other: Symptoms noted were weakness and ataxia.
Gross pathology:
Gross pathology was not carried out.
Other findings:
No further findings.

Any other information on results incl. tables

No further results to report.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
No mortality was seen in this study; the acute oral LD50 is therefore >3200 mg/kg bw.
Executive summary:

Groups of 5 rats were gavaged with a single dose of DMT (in corn oil) at dose levels of 200 -3200 mg/kg bw and observed for 14 days. No deaths occurred; signs of toxicity were limited to weakness and ataxia. Bodyweights were unaffected by treatment. The acute oral LD50 of DMT in the rat was therefore found to be >3200 mg/kg bw under the conditions of this study.