Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 265-148-2 | CAS number: 64742-46-7 A complex combination of hydrocarbons obtained by treating a petroleum fraction with hydrogen in the presence of a catalyst. It consists of hydrocarbons having carbon numbers predominantly in the range of C11 through C25 and boiling in the range of approximately 205°C to 400°C (401°F to 752°F).
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Two studies identified in which the skin sensitising potential of other gas oils was investigated in male Hartley guinea pigs that were dermally exposed to hydrodesulfurised middle distillate (Klimisch scores = 2, API 1984a,b). In the first key study, the test material was administered at a concentration of 25% v/v in paraffin oil for the induction phase and at 10% v/v in paraffin oil for the challenge application. The test material induced slight erythema but no oedema following the challenge application. In the second study, the test material was administered undiluted for the induction phase and at a concentration of 10% v/v in paraffin oil for the challenge application. The test material elicited well-defined erythema and slight oedema during the induction phase but no response upon challenge. Based on the results of these studies, neither sample of hydrodesulfurised middle distillate was a dermal sensitiser in guinea pigs.
Migrated from Short description of key information:
Two studies identified that investigated skin sensitisation of hydrodesulphurised middle distillate. Data show that other gas oils do not induce or elicit allergic skin reactions in the guinea pig (OECD 406).
Justification for selection of skin sensitisation endpoint:
One of two studies with different samples of hydrodesulphurised middle distillate. Both studies negative. Key study selected as it used a higher induction concentration.
Justification for classification or non-classification
Other Gas Oils do not meet the criteria for classification as sensitising to the skin according to EU CLP Regulation (EC No. 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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