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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

direct observations: clinical cases, poisoning incidents and other
Type of information:
other: case report and review
Adequacy of study:
supporting study
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: case report and review

Data source

Reference Type:
Metal fume fever: a case report and review of the literature.
Kaye P, Young H, O’Sullivan I
Bibliographic source:
Emerg Med J 2002; 19:269-269

Materials and methods

Study type:
clinical case study
Endpoint addressed:
acute toxicity: inhalation
Principles of method if other than guideline:
case report

Test material

Constituent 1
Reference substance name:
iron oxide
iron oxide
Details on test material:
metal fume


Type of population:
- Number of subjects exposed: 1
- Sex: male
- Age: 55
Ethical approval:
not applicable
Route of exposure:
Reason of exposure:
intentional, occupational
Exposure assessment:
not specified
Details on exposure:
working as a plumber and on the day of admission had been using an oxyacetylene torch to remove a steel tank
Medical treatment:
Oxygen therapy

Results and discussion

Results of examinations:
On examination, unable to talk in full sentences;
Respiratory rate was 24/min with an oxygen saturation of 94% in room air;
Chest examination was normal;
Pulse rate was 100/min and he was feverish at 39°C;
Blood gas analysis demonstrated acute type I respiratory failure with an arterial oxygen partial pressure of 8.8 kPa;
There was a neutrophil leucocytosis but no other abnormality of baseline pathology;
Chest radiograph revealed patchy opacification in the right perihilar area.
Effectivity of medical treatment:
Full recovery within 1 day
Outcome of incidence:
Metal Fume Fever

Applicant's summary and conclusion

According to the authors, Metal fume fever (MFF) is an acutely noxious inhalation syndrome secondary to metal oxide fumes. Despite preventative strategies sporadic cases are likely to continue to present to emergency departments. MFF is classically associated with zinc oxide fume exposure from welding galvanized steel or brass. It is also seen in association with high temperature zinc coating processes and metal pouring in brass foundries. Magnesium and copper oxide fumes are more rarely the causative agents.
Executive summary:
A case of Metal fume fever (MFF) is described and a short review of the literature on the background, pathogenesis, and clinical presentation of this syndrome is provided. According to the authors MFF is mainly associated with exposure to zinc oxide fume, rarely with magnesium and copper oxide fume. Iron oxide fume is not mentioned.