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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study. Study was conducted in accordance to GLP and OECD guideline 404.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Glycerol, propoxylated
EC Number:
500-044-5
EC Name:
Glycerol, propoxylated
Cas Number:
25791-96-2
Molecular formula:
(C3 H6 O)n (C3 H6 O)n (C3 H6 O)n C3 H8 O3 n=>1-<6.5 mol PO
IUPAC Name:
alpha, alpha’, alpha’’-1,2,3-propanetriyltris[w-hydroxypoly(oxy-methyl-1,2-ethanediyl)]
Details on test material:
Test substance: Propoxylated glycerol mw 300, pure colourless viscous liquid.
Purity: 99.98%, Contains 200 ppm antioxidant.
Polyol 355 UCB
Batch No: 0133759A

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: David Percival, Moston, Cheshire, UK
- Age at study initiation: 12-16 weeks
- Weight at study initiation: 2.40 - 2.79 g

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: none
Controls:
no
Amount / concentration applied:
undiluted
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
Duration of treatment / exposure:
4 hour(s)
Observation period:
1, 24, 48 and 72 hours
Number of animals:
3
Details on study design:
TEST SITE
- Area of exposure: Back of the rabbit, 2.5 cm square
- Type of wrap if used: Surgical adhesive tape and wrapped in an elastic corset


REMOVAL OF TEST SUBSTANCE
- Washing (if done): Gentle swabbing with distilled water
- Time after start of exposure: 4 hours


SCORING SYSTEM: Draize J.H

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
other: 24, 48, 72 mean
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
other: 24, 48, 72 mean
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
other: 24, 48, 72 mean
Score:
0
Max. score:
4
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24, 48, 72 mean
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: 24, 48, 72 mean
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: 24, 48, 72 mean
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: 24, 48, 72 mean
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24, 48, 72 mean
Score:
0
Max. score:
4
Irritant / corrosive response data:
Very slight erythema (grade 1) was observed in one animal only at the 1 hour observation period. All test sites appeared normal at 24 hours.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information
Conclusions:
Propoxylated glycerol mw 300 is not a skin irritant according EU criteria following a 4 hour occlusive exposure to rabbit skin.

Classification: not irritating