Registration Dossier
Registration Dossier
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EC number: 500-044-5 | CAS number: 25791-96-2 1 - 6.5 moles propoxylated
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Glycerol, propoxylated was tested according to OECD Guideline 471 (Bacterial reverse mutation assay), and for chromosomal aberrations in an in vitro cytogenetics assay.. There were negative findings both with and without metabolic activation.
The results from a mammalian point mutation assay have been 'read across' from 2, 2', 2''-nitrilotriethanol, propoxylated. They are negative.
For more information on the read across rationale see report from Paul Illing Consultancy Services Ltd and Marlin Consultancy (Illing and Barratt, 2007). The report identifies that 2, 2', 2''-nitrilotriethanol, propoxylated is the most bioavailable of the polyols linked by an ether group. Since appropriate read-across data are available, no further testing on glycerol propoxylated is warranted. For further details concerning the groupings consult Illing and Barratt ( 2007).
Short description of key information:
Three in vitro mutagenicity tests using different end points were all negative. Therefore further testing is not required.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Findings from in-vitro genotoxicity testing do not warrant classification and labelling according to GHS (EU).
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