Registration Dossier
Registration Dossier
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EC number: 205-500-4 | CAS number: 141-78-6
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1987
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Original study cited not reviewed. Included for completion only using information from a secondary source. Study covers mixed solvent exposure therefore of little use for identifying effects of ethyl acetate alone unless study is completely negative.
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Tuohimaa, P., Wichmann, L.
- Year:
- 1 987
- Bibliographic source:
- Chapter 5 In Hemminki, K. et al. (eds.): Occupational Hazards and Reproduction, Hemisphere Publishing Corp., Washington DC
Materials and methods
- Study type:
- other: no data
- Endpoint addressed:
- toxicity to reproduction / fertility
- Principles of method if other than guideline:
- no further information available.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl acetate
- EC Number:
- 205-500-4
- EC Name:
- Ethyl acetate
- Cas Number:
- 141-78-6
- Molecular formula:
- C4H8O2
- IUPAC Name:
- ethyl acetate
Constituent 1
Method
- Type of population:
- occupational
- Details on study design:
- SETTING: printing factory workers occupationally exposed (for an undisclosed time) to an atmosphere reportedly containing ethyl acetate at 150 ppm (549 mg/m3) and other organic solvents.
STUDY POPULATION
- Total number of subjects participating in study: 11
HEALTH EFFECTS STUDIED
- Other health effects: sperm count. - Exposure assessment:
- not specified
Results and discussion
- Results:
- No effects on sperm count were detected
Applicant's summary and conclusion
- Executive summary:
No effects on sperm count were detected in a study of eleven printing factory workers occupationally exposed (for an undisclosed time) to an atmosphere reportedly containing ethyl acetate at 150 ppm (549 mg/m3) and other organic solvents. The study covered mixed solvent exposure but since the result was negative, it can be concluded that ethyl acetate causes no adverse effects in this exposure setting.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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