Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-126-9 | CAS number: 116-14-3
Endpoint summary
Administrative data
Description of key information
Additional information
Substance is a gas of low solubility and is expected to quickly disappear from the aquatic phase. Therefore, any impact on the aquatic environment is expected to be low. According to 9.1.3 Column 2 of REACH Annex VIII aquatic toxicity studies need not be conducted if there are mitigating factors indicating that aquatic toxicity it unlikely to occur.
Given that tetrafluoroethylene is a gas and the consequent difficulty to test it meaningfully in aquatic media, no experimental aquatic toxicity data are available. Instead, QSAR methods have been used to estimate the acute toxicity of the substance to the aquatic organisms.
The toxicity of TFE to fish, daphnia and algae were estimated using the US EPA program ECOSAR v1.00 (2009).
Predicted acute toxicity to aquatic organisms
| Organisms | Duration (h) | Effect/Parameter | Predicted Concentration (mg/l) |
| Fish | 96 | Lethality LC50 | 379 |
| Daphnia | 48 | Immobility EC50 | 190 |
| Algae | 96 | Growth inhibition | 64 |
The predicted toxic concentrations for fish and daphnia are considerably greater than the solubility limit of TFE in water of 110 mg/l, which was only achievable in equilibrium with a gas phase containing 1 atmosphere of TFE. The predicted Algae EC50 is below the solubility limit; however, experience with other fluorocarbons shows that for this endpoint ECOSAR v1.00 predictions tend to be signifcantly lower than experimental values, and so the predicted algae EC50 of 64 mg/l for TFE may well be conservative. Given that there is no direct or indirect exposure of the aquatic environment to TFE, and that it will disappear rapidly from water, likely concentrations would be orders of magnitude below the solubility limit. Therefore, it is concluded that TFE will not be toxic in the aquatic environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
