Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 272-341-5
CAS number: 68814-87-9
A complex combination of hydrocarbons produced by the distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C9 through C25 and boiling in the range of approximately 150°C to 400°C (320°F to 752°F).
The study methods did not report if single
animals are dosed in sequence, at 48 h intervals as stated in OECD
Reported deviations from protocol include:
Water, purified by reverse osmosis, not tap water, was available ad
libitum to the animals. The rats were fasted overnight for a period of
approximately 19 hours prior to test material administration rather than
16 to 18 hours as stated in the protocol. These deviations are not
considered to have had an effect on the validity of the study.
In an acute oral toxicity study, five male
and five female fasted
Sprague-Dawley, rats were given a single oral dose of a straight run
middle distillate. The test substance was administered undiluted
in a single gavage dose of 5000 mg/kg body weight. The animals
were observed for 14 days.
Clinical signs observed during the
study period included hypoactivity, ataxia, diarrhoea, lacrimation, oily
yellow-stained coat, and hair loss. No mortality was observed. Body
weights in both males and females had increased at day 7 and continued
to increase at 14 days post-treatment.
The oral LD50 for straight run middle
distillate in male and female rats was greater than 5000 mg/kg body
This study received a Klimisch score
of 1 and is classified as reliable without restriction because it was
conducted according to or similar to guideline study OECD TG 401.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again