Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

A straight run middle distillate was tested using the Buehler method for dermal sensitisation in guinea pigs (API, 1985a; Klimisch score=1). The test substance (0.4 millilitres) was applied undiluted during the induction phase (three applications under occlusion, once per week for 3 weeks), and as a 1% volume/volume dilution in paraffin oil during the challenge phase, to groups of ten male guinea pigs. A positive control group (2,4-dinitrochlorobenzene in 80% aqueous ethanol, 0.3% for induction, 0.1% for challenge, as above in twenty animals), a vehicle control group (undiluted paraffin oil in ten animals) and a naive control (0.4 millilitres of 1% dilution of test sample during challenge only in ten animals) were also included in this study. The sites were examined for erythema and oedema at 24 and 48 hours following each application according to the method of Draize. Following challenge, very slight erythema was exhibited by a single animal however the intensity of the reaction did not exceed the highest response recorded in the naïve control animals. The other test animals exhibited no reaction following challenge. Positive controls had the appropriate response.

Based on these results, straight run gas oils are not skin sensitisers under the conditions of the test.

Migrated from Short description of key information:

A key skin sensitisation study (OECD 406) was identified on straight run middle distillate.  In this Buehler study, the test material was not sensitising to guinea pigs.

Justification for selection of skin sensitisation endpoint:

well conducted guideline study

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:

This endpoint is not a REACH requirement. Furthermore no information was available.

Migrated from Short description of key information:

This endpoint is not a REACH requirement. Furthermore no information was available.

Justification for classification or non-classification

Based on information from a key skin sensitisation study, straight run gas oils do not meet the criteria for classification as a dermal sensitiser under the EU CLP Regulation (EC No. 1272/2008).