Ferrosilicon - reaction mass of iron and iron disilicide and iron silicide and silicon

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well reported, meets basic scientific standard. Read-across to silicon.

Data source

Reference

Reference Type:

publication

Title:

Dietary silicon intake and absorption.

Author:

Jugdaohsingh, R., S. H. Anderson, et al.

Year:

2002

Bibliographic source:

Am J Clin Nutr.75(5): 887-93.

Materials and methods

Type of study / information:

Data on the intake of silicon via the food

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

Silicon intakes were determined in cohorts from the original Framingham Study and the Framingham Offspring Study (n=5209 men and women) by using a 126-item food-frequency questionnaire. Gastrointestinal uptake of silicon from foods was estimated in 3-8 healthy subjects by using urinary silicon excretion as a surrogate measure of silicon uptake.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

silicon in different forms

IUPAC Name:

silicon in different forms

Results and discussion

Any other information on results incl. tables

Mean silicon intakes in men (30 and 33 mg/d in the original Framingham and Framingham Offspring cohorts, respectively) were significantly higher than those in women (24 and 25 mg/d in the 2 cohorts, respectively; P = 0.0001). Silicon intake decreased with age (P < 0.001, adjusted for sex). The major food sources were beer and bananas in men and bananas and string beans in women. Silicon was readily available from foods; a mean of 41% of the ingested silicon was excreted in urine. The silicon content of the foods consumed was significantly correlated with urinary silicon excretion (P = 0.019).

Applicant's summary and conclusion

Conclusions:

The major food sources of silicon are beer, bananas in men and string beans. Silicon is readily available from foods. The silicon content of the foods consumed correlates with urinary silicon excretion.

Executive summary:

Jungdaohsignh et al. (2002) studied the dietary intake of silicon among a cohort of 5,209 men and women and studied also gastrointestinal uptake of silicon among 3-8 healthy subjects. The major food sources of silicon are beer, bananas in men and string beans. Silicon is readily available from foods. The silicon content of the foods consumed correlates with urinary silicon excretion.