1-Butanone, 2-(dimethylamino)-2-[(4-methylphenyl)methyl]-1-[4-(4-morpholinyl)phenyl]-

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2002

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

other: European Commission, "Particle Size Distribution, Fibre Length and Diameter Distribution" Guidance Document, ECB/TM/February 1996.

Deviations:

not specified

GLP compliance:

yes

Type of method:

Laser scattering/diffraction

Type of distribution:

volumetric distribution

Mass median aerodynamic diameter:

16.7 µm

Percentile:

D50

Mean:

< 16.7 µm

St. dev.:

1.499

Percentile:

D10

Mean:

< 1.5 µm

St. dev.:

0.428

Percentile:

D90

Mean:

< 40.1 µm

St. dev.:

6.591

A solubility test showed, that the test item is both: sparingly soluble and well dispersible in water containing 0.2 g/l sympatens SHO/400. For the particle size distribution measurement the test item was dispersed two times in pre-saturated water

The particle size distribution was found to range from approximately 0.3 µm to 100 µm.

The mass median diameter was determined to be 16.7 µm.

Conclusions:

The particle size distribution of test substance was measured to be MMD=16.7 µm

Executive summary:

In this EC guideline study conducted to GLP standards, the test material (EC 438-340-0) was determined to have a particle size distribution of MMD=16.7 µm.

Description of key information

Study conducted to recognised testing guidelines with GLP.

Additional information

MMD= 16.7µm
D10= 1.5µm
D90= 40µm

Particle size distribution ranges from approx. 0.3 to 100µm.