Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 273-688-5
CAS number: 69011-06-9
In assessing the ecotoxicity of metals in the various environmental
compartments (aquatic, terrestrial and sediment), it is assumed that
toxicity is not controlled by the total concentration of a metal, but by
the bioavailable form. For metals, this bioavailable form is generally
accepted to be the free metal-ion in solution. In the absence of
speciation data and as a conservative approximation, it can also be
assumed that the total soluble lead pool is bioavailable. All reliable
data on ecotoxicity and environmental fate and behaviour of lead and
lead substances were therefore selected based on soluble Pb salts or
measured (dissolved) Pb concentration.
The reliable ecotoxicity data selected for effects assessment of Pb in
the various environmental compartments are derived from tests with
soluble Pb salts (lead (di)nitrate, lead carbonate, lead acetate, lead
chloride). Since lead is the toxic component and the anions do not
contribute to toxicity, all reliable data are grouped together in a
read-across approach and the PNECs are expressed as µg Pb/L (measured
dissolved concentration) of mg/kg Pb. These results can be used for all
other Pb compounds without considering toxicity of the anions.
Attached are documents discussing the PNEC derivation for the aquatic,
terrestrial, and sediment environments, and secondary poisoning via the
terrestrial food chain, which describe the process in detail.
For ERV derivation the general rules according to the ‘Guidance on the
application of the CLP criteria' (ECHA, 2015) has been followed.
Therefore, the determination of the environmental acute/chronic hazard
assessment for Pb is based on data that were generated according to
standardised test methods (or from validated and internationally
accepted test methods). For acute ERV derivation LC50values were used,
while for chronic ERV derivation, NOECs or the equivalent L(E)C10were
used. Unbounded toxicity values were not further considered for ERV
derivation. Additionally, no marine species were considered.
Furthermore, where 4 or more ecotoxicity data on the same species and
endpoint were available, the data were grouped, and the geometric mean
used as a representative toxicity value for that species. In other cases
(> 4 data points), the lowest representative toxicity value was selected.
It is further noted that this substance is included in Regulation (EC)
No 1272/2008 Annex VI Table 3.1 under the entry “lead compounds with the
exception of those specified elsewhere in this Annex (Index No
082-001-00-6). As such, this harmonised classification is legally
For the classification of metals, Transformation/Dissolution is carried
out over a pH range. Ideally both T/D and ecotoxicity data are compared
at a similar pH since both parameters will vary with pH. Because T/Dp
tests are typically performed between pH 5.5 - 8.5, we have 'separated'
the toxicity data according to 3 different pH ranges, i.e. 5.5 -6.5/6.5
- Acute reference values
An overview of the selected high
quality species mean/lowest acute toxicity data for the 3 different pH
classes is provided in the table
Overview of the selected high quality short-term toxicity data for
the individual species (L(E)C50values expressed as µg/L) for
the 3 pH classes (lowest values in bold):
Geometric mean/lowest value
OECD n° 221
OECD n° 201
OECD n° 201
OECD n° 202
OECD n° 203
stricto, the species Chlorella
vulgaris should be used
according to the OECD guideline. However, both species belong to the
same genus and therefore Chlorella kessleri was selected for
/: no data available
- Chronic reference values
An overview of the selected high
quality species mean/lowest chronic toxicity data for the 3 different pH
classes is provided in the table below.
Overview of the selected high quality long-term toxicity data for
the individual species (L(E)C10/NOEC values expressed as
µg/L) for the 3 pH classes (lowest values in bold):
Most sensitive endpoint
OECD n° 201
OECD n° 211
ASTM n° E1295-01
OECD n° 204; OECD n° 210; OECD n° 212
OECD n° 210
stricto, the speciesC
hlorella vulgaris should
be used according to the OECD guideline. However, both species
belong to the same genus and therefore Chlorella kessleri was
selected for classification purposes
A summary of the selected acute and
chronic reference values at the different pHs is provided in the table
Overview of the selected high quality
acute and chronic toxicity data for the individual species (expressed as
µg dissolved Pb/L) for the 3 pH classes
Reference values (µg dissolved Pb/L)
Acute reference value
Chronic reference value
In any case, this substance is included in Regulation (EC) No
1272/2008 Annex VI Table 3.1 under the entry “lead compounds
with the exception of those specified elsewhere in this Annex
(Index No 082-001-00-6). As such, the harmonised classification
of Acute 1, Chronic 1 is legally binding.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again