Registration Dossier
Registration Dossier
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EC number: 600-198-4 | CAS number: 101377-47-3
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No analytical monitoring
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Remarks:
- Conducted according to guideline in effect at time of study conduct
- GLP compliance:
- yes
Test material
- Reference substance name:
- bis(4-fluorophenyl)methyl(4H-1,2,4-triazol-4yl-methyl)silane
- EC Number:
- 600-198-4
- Cas Number:
- 101377-47-3
- Molecular formula:
- C16H15N3F2Si
- IUPAC Name:
- bis(4-fluorophenyl)methyl(4H-1,2,4-triazol-4yl-methyl)silane
- Details on test material:
- - Purity: R7623 Technical, solid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- yes
Test organisms
- Test organisms (species):
- Poecilia reticulata
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 5.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 4.7 - 9.8 mg/L
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: at 1.8 mg/L fish showed decreased swimming ability; at 3.2 and 5.6 mg/L: increased pigmentation, decreased swimming ability and mortality in 2 out of 10 fish
Any other information on results incl. tables
- Sublethal observations / clinical signs:
After 24 hours of exposure 100% mortality was observed at 10 mg/L.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- 96-h LC50 = 5.7 mg/L
- Executive summary:
An acute, static 96-hour test was conducted at nominal concentrations of 0, 0.56, 1.0, 1.8, 3.2, 5.6 and 10.0 mg/L on Poecilia reticulata. Exposure after 24 hours resulted in 100% mortality at 10 mg/L. Based on nominal concentration , the EC50 was 5.7 mg/L and the NOEC was 1 mg/L.
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