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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well documented study

Data source

Reference
Reference Type:
publication
Title:
Zur arbeitshygienisch-toxikologischen Beurteilung volkswirtschaftlich bedeutsamer chemischer Substanzen. 4. Kurzmitteilung: Technisches 2-Aethylhexylacetat (Octylacetat).
Author:
Schmidt P, Bachmann W
Year:
1969
Bibliographic source:
Z Gesamte Hyg. 15(12): 928-929

Materials and methods

Principles of method if other than guideline:
Study to assess the acute oral toxicity in rats.
GLP compliance:
no
Test type:
other: no data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexyl acetate
EC Number:
203-079-1
EC Name:
2-ethylhexyl acetate
Cas Number:
103-09-3
Molecular formula:
C10H20O2
IUPAC Name:
2-ethylhexyl acetate
Details on test material:
2-ethylhexyl acetate, technically pure

Test animals

Species:
rat
Strain:
other: albino
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: own breeding (randomized)
- Weight at study initiation: 161 (150-180) g
- Fasting period before study: 18 h
- Diet Standard diet K (VEG Altglienecke, Germany) ad libitum
- Water ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
no data
Doses:
4 doses (unspecified)
No. of animals per sex per dose:
10
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 4 weeks (necropsy)
Statistics:
The calculation of the LD50 was done according to Litchfield and Wilcoxon. The differences were significant, if p<0.05 was calculated in the t-test.

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
5 140 mg/kg bw
95% CL:
4 450 - 5 950
Remarks on result:
other: value 48 h after administration
Mortality:
Deaths occurred predominantly within the first 24 hours after appliaction.
Clinical signs:
Little excitation, narcosis.
Body weight:
The animals recovered sufficiently after marked weight loss.
Gross pathology:
Animals that died: Uncharacteristic blood congestion in the interior organs.
Sacrificed animals: no macroscopic changes were observed after the autopsy.

Applicant's summary and conclusion

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