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EC number: 223-768-0 | CAS number: 4062-46-8
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The hydrolytic stability of mesterolonacetat could not be determined experimentally, since the solubility in water is below the analytical detection limit.Therefore, an estimation, on basis of the hydrolytic behavior of a structurally similar compound was made.
General Physical Chemistry, Schering AG, Berlin. Study report MR28 (APC 18/98), dated 1998-02-26.
Result: Mesterolonacetat can be expected to be hydrolytically stable at pH4 and pH7 and to hydrolyse with a half-life of approx. 27 days at pH 9 (at 25°C).
Key value for chemical safety assessment
Additional information
Since the water solubility of the test substance was found to be smaller than the detection limit of the analytical method (< 0.0028 mg/L), no experimental determination of the rate of hydrolysis could be performed. The hydrolytic behaviour is expected to be similar to that of the structurally closely related compound 17beta-acetoxy-5alpha-androst-1 -en-3 -one, which differs only by the double bond 1-en and the missing methyl group in postion 1 of ring A. The only hydrolyzable functional group in both molecules is the ester function in position 17.
The rate of hydrolysis of 17beta-acetoxy-5alpha-androst-1 -en-3 -one was determined according to EC guideline C.7 at pH 4, 7 and 9. This compound is hydrolytically stable at pH 4 and pH 7 at 25 °C. The half-life at pH 9, 25 °C is 27 days.
Comparable results are to be expected for mesterolonacetat.
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