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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: well reported GLP study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1996
Report date:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
17β-hydroxy-1α-methyl-5-αandrostan-3-one acetate
EC Number:
223-768-0
EC Name:
17β-hydroxy-1α-methyl-5-αandrostan-3-one acetate
Cas Number:
4062-46-8
Molecular formula:
C22H34O3
IUPAC Name:
1-methyl-3-oxoandrostan-17-yl acetate

Sampling and analysis

Analytical monitoring:
yes

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
48 h

Results and discussion

Effect concentrations
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
< 1 mg/L
Nominal / measured:
meas. (arithm. mean)
Conc. based on:
act. ingr.
Basis for effect:
mobility

Any other information on results incl. tables

No adverse effects were observed. Therefore, the EC50 is higher than a saturated solution determined with <1 mg/L

Applicant's summary and conclusion

Conclusions:
No adverse effects were observed.
Executive summary:

The toxicity of the test substance was studied in an acute immobilization test on Daphnia magna in a limit test according to OECD202. The test organisms were exposed over a period of 48 hours to a saturated solution of the test substance. No adverse effects were observed. Therefore, the EC50 is higher than a saturated solution determined with <1 mg/L. The study was perfomed under GLP (Schering report X185, 13 Jan 1997).