Registration Dossier
Registration Dossier
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EC number: 942-741-0 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary quotation
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
- Reference Type:
- publication
- Title:
- A toxicologic and dermatologic assessment of ionones when used as fragrance ingredients
- Author:
- D. Belsito, D. Bickers, M. Bruze, P. Calow, H. Greim, J.M. Hanifin, A.E. Rogers, J.H. Saurat, I.G. Sipes, H. Tagami
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology 45 (2007) S130–S167
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Irritation was evaluated daily during the associated 90 day study
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one
- EC Number:
- 204-846-3
- EC Name:
- 3-methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one
- Cas Number:
- 127-51-5
- Molecular formula:
- C14H22O
- IUPAC Name:
- 3-methyl-4-(2,6,6-trimethylcyclohex-2-en-1-yl)but-3-en-2-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
Test system
- Type of coverage:
- open
- Preparation of test site:
- other: clipped
- Vehicle:
- not specified
- Controls:
- other: 30 female and 30 male, clipped at same frequency as test group
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 - 2000 mg/kg bw - Duration of treatment / exposure:
- daily for 90 days
- Observation period:
- daily for 90 days
- Number of animals:
- 15/sex/dose
Results and discussion
In vivo
Results
- Remarks on result:
- other: no scores determined
Any other information on results incl. tables
Irritant effects, erythema and edema with eschar formation was observed at all dose levels
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
