Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from test report

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1996

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD 401 EEC GUIDELINES B.1 , Section 4.1.1
Principles of method if other than guideline:
Data is from test report
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
421-450-8
EC Name:
-
Cas Number:
154702-15-5
Molecular formula:
C44H59N7O5
IUPAC Name:
Bis(2-ethylhexyl) 4,4’-{6-[4-tert-butylcarbamoyl)anilino]-1,3,5-triazine-2,4-diyldiimino}dibenzoate
Constituent 2
Reference substance name:
bis(2-ethylhexyl) 4,4’-{6-[4-tert-butylcarbamoyl) anilino]-1,3,5-triazine-2,4-diyldiimino}dibenzoate
IUPAC Name:
bis(2-ethylhexyl) 4,4’-{6-[4-tert-butylcarbamoyl) anilino]-1,3,5-triazine-2,4-diyldiimino}dibenzoate

Test animals

Species:
rat
Strain:
other: SPRAGUE DRAWLEY Crl: CD BR RATS
Sex:
not specified

Administration / exposure

Route of administration:
oral: drinking water
Vehicle:
other: 0.5% METHYLCELLULOSE WATER SOLUTION
No. of animals per sex per dose:
Male: Number of animals: 5;
Female: Number of animals: 5

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Mortality:
Male: > 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: > 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
No clinical signs or behavioural alterations were observed
in any rat. No animals died during the observation period.
Gross pathology:
Effects on organs:
Body weight gains was considered within normal limits for animal of this strain and age. At the autopsy carried out at the end of the observation period no appreciable macroscopic findings were evident in any treated rats.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The Acute toxicity (LD50) values of test material was found to be >2000 mg/kg for male and female rats.
Executive summary:

The Acute toxicity (LD50) values of test material was found to be >2000 mg/kg for male and female rats.

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