Registration Dossier
Registration Dossier
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EC number: 255-272-5 | CAS number: 41233-93-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No data are available on the repeated dose toxicity of potassium 2-methylbutan-2-olate. The test substance is used as transported intermediate in a closed system. Under the strictly controlled conditions repeated exposure of workers is not expected. Due to the corrosive nature of the test substance, is it unlikely that repeated human exposure occurs under normal handling and use conditions.
According to the REACh regulation (EC) No 1907/2006, Article 18.2 further testing is not required. In vivo testing with corrosive substances at concentrations causing corrosivity shall be avoided, as pointed out in the introductions to Annexes VII-X of the REACh Regulation (EC) No 1907/2006. The test substance is classified as corrosive to skin according to the CLP regulation (EC) No 1272/2008.
Justification for classification or non-classification
The test substance hydrolyses rapidly in the presence of water. Therefore, the hydrolysis products are considered to be relevant for classification according to CLP regulation (EC) No 1272 /2008.
For the hydrolysis products potassium hydroxide (CAS No. 1310-58-3) and 2 -methylbutan-2 -ol (CAS No. 75-85-4) disseminated dossiers are available on the homepage of ECHA. The hydrolysis products are not classified for repeated dose effects. Due to this reason, a classification of the test substance for repeated dose effects is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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