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EC number: 282-968-6
CAS number: 84501-49-5
48h LC50 (Cyprinus carpio pre-larvae, mortality) = 13 mg/L (nominal concentration, Japanese Industrial Standard JIS K0102)96h LC50 (Cyprinodon variegates) = 4.1 mg/L (measured concentration, marine water, ASTM E-35 1980)
Since no reliable short-term fish test is available for C9-11AS Na (CAS
84501-49-5), in accordance to Regulation (EC) No. 1907/2006 Annex XI,
1.5, a read-across to other structurally related category members was
conducted. Read-across data from the following substances were used:
C10AS Na (CAS 142-87-0) and C12AS Na (CAS 151-21-3). Toxicity of alkyl
sulfates is dependent on the carbon chain length.
In the key, non-GLP study performed according to Japanese Industrial
Standard JIS K0102, 1-week old carp pre-larvae (Cyprinus carpio) were
exposed to C10AS Na for 48 hours under static conditions (Kikuchi et al.
1976a). Based on pre-larvae mortality, the LC50 value was 13 mg/L
(nominal concentrations in agreement with the measured ones). Since the
obtained value was the most critical, it is considered as a reliable
short-term LC50 value for fish. The same authors provide supporting
information on Carp egg hatching rate influenced by C10AS Na (Kikuchi
1976b). Fish eggs were exposed for 96 hours to the test concentrations
up to 100 mg/L (nominal concentrations in agreement with the measured
ones). The study followed Japanese Industrial Standard JIS K0102.
Inhibition of hatching rate could not be calculated because hatching
rate was higher at 70 mg/L (ca. 40%) than at 50 mg/L (ca. 12%). No
hatching at 100 mg/L was observed. Hatching rate in the control group
was 87.3%. Another supporting, non-GLP study performed according to ISO
7346-1 guidance is available (Richterich 2001). Mortality of zebrafish
(Danio rerio) was determined after 24, 48, 72 and 96 hours of exposure
to five test concentrations up to 1000 mg/L of product containing 30% of
active ingredient and 70% water (nominal concentrations). Analytical
monitoring was not performed. The results showed that the 96-hour LC50
value was 177 mg a.i./L (nominal concentration).
Toxic effects of C12AS Na (CAS 151-21-3) to fathead minnow (Pimephales
promelas) were studied in a non-GLP test performed similar to OECD
guideline 203 (Rawlings 2004). Fish were exposed in a flow-through
system to five test concentrations up to 48 mg/L of nominal
concentration, corresponding to 40 mg/L of measured concentration.
Mortality of fish was evaluated every 24 hours. The test substance was
determined to have an 96-hour LC50 of 29 mg/L (measured concentration).
Moreover, the short term effects of C12AS Na (CAS 151-21-3) were studied
on the marine sheepshead minnow Cyprinodon variegatus (Roberts et al.
1982). This non-GLP test was performed according to ASTM E-35 (1980)
method. Fish were exposed to five test concentrations in brackish water
(salinity 10 ‰) under static conditions. The 96h LC50 value of 4.1 mg/L
was determined (measured concentration).
Due to structural and property similarities with the tested category
members, it can be concluded that the above results apply also to
C9-11AS Na (CAS 84501-49-5). The LC50 value to freshwater fish is
assumed to be 13 mg/L and to marine fish 4.1 mg/L.
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