Registration Dossier
Registration Dossier
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EC number: 811-460-4 | CAS number: 53606-41-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- Aqua pro injectione
- Doses:
- 3 doses, 300 mg/kg and 2000 mg(kg
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
- Clinical signs:
- other: No clinical signs of intoxication were observed during the study
- Gross pathology:
- No pathologic macroscopic changes were diagnosed during pathological examination
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
The test substance toxicity was evaluated on the basis of mortality, clinical signs of intoxication, body weight increments during the observation period and necropsy findings at the end of study. The test substance administered at the dose of 300 and 2000 mg/kg caused no death of animals. No clinical signs of intoxication were detected during the whole study in all nine animals. No pathologic macroscopic changes were diagnosed during pathological examination. According to the study results the value of LD50 of the test substance, 2-methoxy-5-nitrophenyl acetate, for female rats is higher than 2000 mg/kg of body weight.
Reference
| Dose | Number and sex of animals | Mortality | Clinical Signs of intoxication | Pathological findings |
| 300 mg/kg | 3 females, step no. 1 | 0 | 0 | 0 |
| 2000 mg/kg | 3 females, step no. 2 | 0 | 0 | 0 |
| 2000 mg/kg | 3 females, step no. 3 | 0 | 0 | 0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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