Registration Dossier
Registration Dossier
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EC number: 203-564-8 | CAS number: 108-24-7
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable publication, reasonably validated
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on eye irritation caused by chemicals in rabbits -1. A quantitative structure-activity relationships approach to primary eye irritation of chemicals in rabbits.
- Author:
- Sugai S et al.
- Year:
- 1 990
- Bibliographic source:
- J Toxicol Sci 15: 245-262
Materials and methods
- Principles of method if other than guideline:
- A structure-activity relationship (QSAR) approach has been applied to the analysis of the relation between the structural features of chemicals and the primary eye irritation in rabbits. One hundred thirty one heterogeneous chemicals including medicals, pesticides, detergents and organic solvents were used in this study. The eye irritation ratings were made in three classes on the basis of the recovery time of corneal and conjunctival damages. Thirty six descriptors were used to describe the molecules.
- Type of method:
- other: QSAR
- Endpoint addressed:
- eye irritation
Test material
- Reference substance name:
- Acetic anhydride
- EC Number:
- 203-564-8
- EC Name:
- Acetic anhydride
- Cas Number:
- 108-24-7
- Molecular formula:
- C4H6O3
- IUPAC Name:
- acetyl acetate
- Details on test material:
- - Name of test material (as cited in study report): Acetic anhydride
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Takeo breeder (Shizuoka, Japan)
- Weight at study initiation: 2.0-2.2 Kg
- Diet (e.g. ad libitum): RC4 diet
- Water (e.g. ad libitum): tap water
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 25±1
- Humidity (%): 55±5
- Photoperiod (hrs dark / hrs light): 12/12
Results and discussion
- Details on results:
- The accuracy in classifying the chemicals was 86.3% in the recognition and 74.0% in the leave-one-out prediction. These results suggest that QSAR analysis is valuable to predict the primary eye irritation of chemicals.
Any other information on results incl. tables
Based on the results, acetic anhydride was classified as corrosive.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
