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Short-term toxicity to fish

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Description of key information

The predicted data suggests the effective concentration (EC50) for the test compound PyrazoloneTwas estimated to be 572.70123291mg/L on the basis of mortality. 

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
572.701 mg/L

Additional information

Various predicted data for chemical PyrazoloneTalong with its read across substance were reviewed to summarize the following information: 

48 hrs aquatic toxicity study (SSS QSAR prediction model, 2016) was conducted to assess toxic effects of the test compound PyrazoloneT(CAS no 118-47-8) and the results were predicted. The study was based on the effects of the test compound on the Zebra fish in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound PyrazoloneTwas estimated to be 572.70123291mg/L on the basis of mortality. 

 

48 hrs aquatic toxicity study (EPI suite, 2016) was conducted to assess toxic effects of the test compoundPyrazoloneT(CAS no118-47-8) and the results were predicted. The study was based on the effects of the test compound on fish in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the test compoundPyrazoloneTwas estimated to be 6.46 x 105mg/l. 

 

Short term toxicity study (Yaushide TONOGAL, Masahiro IWAIDA, Masatomo TATI, Youki OSE and Takahiko SATO,1978) toOryzias latipeswas carried out for 48 hrs and survival rate (in %) was determined. Himedaka (Oryzias latipes) of same age (2 cm long and 0.2 in weights) was used for the study. The test fishes were acclimatized for 10 days in tap water. In 1 litre solution of pH 7.0 containing 3,000 mg/l of test substance Tartrazine, ten fishes were kept in the tank without direct sunlight for 48 hrs and survival rate was determined. Water temperature was 20C and aeration was provided with bubbler. Median Tolerance Limit (TLm) was also determined after 24 and 48 hrs. The TLm value was not reported. As no mortality of test animal was observed after 48 hrs, the LC0 value was found to be 3,000 mg/l. Thus, the survival rate of fish after 48 hrs was found to be 100%.

Short term toxicity study (Data bank of Environmental Properties of Chemicals (EnviChem))toOryzias latipeswas carried out for 48 hrs. The 48 hrs LC50 value to test organismOryzias latipeswas found to be greater than 1000 mg/l.

 

 

On the basis of results of various predictions and read across, the chemicalPyrazoloneT can be considered as not likely to be toxic to fishes at environmentally relevant concentrations and can be classified as non- hazardous as per the criteria of CLP regulation