Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 240-005-7 | CAS number: 15876-39-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
In accordance with column 1 of Annex VIII of the REACH regulation, assessment of the toxicokinetic behaviour of the substance needs to be provided to the extent that can be derived from the relevant available information. There is no available information on the toxicokinetic behaviour of the substance Dialuminium tris[2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate] (Common Name: D&C Red 21 Lake, C.I. No 45380:3). The chemical is used as a coloring ingredient in cosmetics and personal care products and thus, oral absorption of this chemical is highly unlikely. However, there is a possibility of dermal absorption from the skin surfaces where the chemical is applied.
Experimentally it has been found that this chemical has very low solubility in water. Thus, the chemical is likely to have high Log Pow (Octanol-water partition coefficient value) > 5. According to the Lipinski rule of 5, a drug/chemical having Log Pow > 5 shall not be bio-available within the living system and thus even if absorbed dermally, shall not be metabolized and therefore shall be excreted out of the living system mostly unchanged either through the urine or feaces. In such a scenario, the bio-accumulation potential is expected to be low.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
In accordance with column 1 of Annex VIII of the REACH regulation, assessment of the toxicokinetic behaviour of the substance needs to be provided to the extent that can be derived from the relevant available information. There is no available information on the toxicokinetic behaviour of the substance Dialuminium tris[2-(2,4,5,7-tetrabromo-6-oxido-3-oxoxanthen-9-yl)benzoate] (Common Name: D&C Red 21 Lake, C.I. No 45380:3). The chemical is used as a coloring ingredient in cosmetics and personal care products and thus, oral absorption of this chemical is highly unlikely. However, there is a possibility of dermal absorption from the skin surfaces where the chemical is applied.
Experimentally it has been found that this chemical has very low solubility in water. Thus, the chemical is likely to have high Log Pow (Octanol-water partition coefficient value) > 5. According to the Lipinski rule of 5, a drug/chemical having Log Pow > 5 shall not be bio-available within the living system and thus even if absorbed dermally, shall not be metabolized and therefore shall be excreted out of the living system mostly unchanged either through the urine or feaces. In such a scenario, the bio-accumulation potential is expected to be low.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
