Registration Dossier
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EC number: 224-618-7 | CAS number: 4430-18-6
Endpoint summary
Administrative data
Description of key information
Additional information
Short term toxicity to aquatic invertebrates:
Prediction model based estimation was done to estimate the short term aquatic invertebrates toxicity of the test compound Acid violet 43 (CAS no 4430 -18 -6). The summary is as below:
The median Effective concentration (EC50) value for sodium 4-[(9,10-dihydro-4-hydroxy-9,10-dioxo-1-anthryl)amino]toluene-3-sulphonate on Daphnia magna in a 48 hour study was estimated to be 143 mg/L on the basis of intoxication effects.
Danish QSAR estimation database (2016) estimated the median effective concentration (EC50) for the test compound sodium 4-[(9,10-dihydro-4-hydroxy-9,10-dioxo-1-anthryl)amino]toluene-3-sulphonate in a 48h study using daphnids to be 22.71 mg/L.
Thus the chemical is not expected to exhibit aquatic toxicity as per the CLP criteria.
Toxicity to algae and cyanobacteria:
Experimental data and prediction model based estimation was used to evaluate the algal toxicity of the test compound Acid violet 43. the summary is as below:
The effect of test item sodium 4-[(9,10-dihydro-4-hydroxy-9,10-dioxo-1-anthryl)amino]toluene-3-sulphonate, CAS No. 4430-18-6 was studied on the growth of fresh water green algaChlorella vulgaris.The study was conducted following OECD guideline 201- Alga, growth inhibition test. The test concentration chosen for the study were 6.25mg/l, 12.5mg/l, 25mg/l, 50mg/l, 100mg/l and 200mg/l. The test concentrations were prepared using stock solution of the test item using mineral media. The green alga was exposed to the test concentration for a period of 72 hours to observe average specific growth rate and % growth inhibition under the effect of the test item. EC50 calculated graphically through probit analysis was observed to be 79.788mg/L.
The median effective concentration (EC50) for the test compound sodium 4 -[(9,10 -dihydro-4 -hydroxy-9,10 -dioxo-1 -anthryl)amino]toluene-3 -sulphonate as predicted by Danish QSAR estimation database in a 96h study using green algae is found to be 25.528 mg/L.
Experimental data suggests that the test chemical does not classify for toxicity to algae and cyanobacteria.
As per the CLP criteria, the test chemical (CAS no 4430 -18 -6) does not classify for aquatic toxicity.
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