Registration Dossier
Registration Dossier
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EC number: 200-911-5 | CAS number: 75-87-6
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic/sediments:
The bioaccumulation study was conducted on fish for determining the BCF (bioaccumulation factor) value of test chemical. The BCF (bioaccumulation factor) was calculated using a log Kow of 1.2 and a regression-derived equation. The BCF (bioaccumulation factor) of test chemical was determined to be 5 dimensionless which does not exceed the bioconcentration threshold of 2000, indicating that the chemical is non-bioaccumulative in aquatic organisms.
Additional information
Bioaccumulation: aquatic/sediments:
Various experimental study and predicted data for the test chemical and its structurally similar read across chemical were reviewed for the bioaccumulation end point which are summarized as below:
The first bioaccumulation study was conducted on fish for determining the BCF (bioaccumulation factor) value of test chemical. The BCF (bioaccumulation factor) was calculated using a log Kow of 1.2 and a regression-derived equation. The BCF (bioaccumulation factor) of test chemical was determined to be 5 dimensionless which does not exceed the bioconcentration threshold of 2000, indicating that the chemical is non-bioaccumulative in aquatic organisms.
In another study the BCFBAF model (v3.01) of Estimation Programs Interface (EPI Suite, 2020) program was used to predict the bioconcentration factor (BCF) of test chemical. The bioconcentration factor (BCF) of test chemical was estimated to be 3.162 L/kg whole body w.w at 25 °C which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is non-bioaccumulative in nature.
In next study using Bio-concentration Factor (v12.1.0.50374) module, the BCF over the entire pH scale (pH 0 - 14) of the test chemical was estimated to be 9.85 (log BCF = 1.0 ± 1.0). This value indicates that the test chemical was considered to be non-bioaccumulative in aquatic organisms.
In last bioaccumulation study in fish was conducted for estimating the BCF (bioaccumulation factor) value of test chemical. The bioaccumulation factor (BCF) value was calculated using a log Kow of 0.99 and a regression-derived equation. The estimated BCF (bioaccumulation factor) value of test chemical was determined to be 3 dimensionless, which does not exceed the bioconcentration threshold of 2000, indicating that the test chemical is considered to be non-bioaccumulative in aquatic organisms.
On the basis of above results for test chemical, it is concluded that the BCF value of test chemical ranges from 3.162 – 9.85 dimensionless which does not exceed the bioconcentration threshold of 2000, indicating that the chemical is not expected to bioaccumulate in the food chain.
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