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Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from IFA GESTIS authoritive database

Data source

Reference
Reference Type:
other: Authoritive Database
Title:
Skin irritation test for 4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1)
Author:
IFA GESTIS
Year:
2017
Bibliographic source:
GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Principles of method if other than guideline:
Skin irritation study of 4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1) was conducted on rabbits to determine its potential of causing skin irritation according to OECD 404.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
4-chloro-2,5-dimethoxyaniline
EC Number:
228-782-0
EC Name:
4-chloro-2,5-dimethoxyaniline
Cas Number:
6358-64-1
Molecular formula:
C8H10ClNO2
IUPAC Name:
4-chloro-2,5-dimethoxyaniline
Details on test material:
- IUPAC Name: 4-chloro-2,5-dimethoxyaniline
- Mol. formula: C8H10ClNO2
- Molecular Weight: 187.625 g/mole
- Smiles: c1(c(cc(OC)c(c1)Cl)N)OC
- InChI: 1S/C8H10ClNO2/c1-11-7-4-6(10)8(12-2)3-5(7)9/h3-4H,10H2,1-2H3
Specific details on test material used for the study:
- IUPAC Name: 4-chloro-2,5-dimethoxyaniline
- Mol. formula: C8H10ClNO2
- Molecular Weight: 187.625 g/mole
- Smiles: c1(c(cc(OC)c(c1)Cl)N)OC
- InChI: 1S/C8H10ClNO2/c1-11-7-4-6(10)8(12-2)3-5(7)9/h3-4H,10H2,1-2H3

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data available

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
No data available
Duration of treatment / exposure:
No data available
Observation period:
No data available
Number of animals:
No data available
Details on study design:
No data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No skin irritation was observed I treated rabbits.

Applicant's summary and conclusion

Interpretation of results:
other: Not irritating
Conclusions:
The test material 4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1)was considered to be not irritating to the rabbits’ skin.
Executive summary:

Skin irritation study of 4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1) was conducted on rabbits to determine its potential of causing skin irritation according to OECD 404.

 

The chemical did not produce any adverse skin effects when applied dermally.

 

Therefore under the test condition, the chemical 4-Chloro-2,5-dimethoxyaniline (CAS no: 6358-64-1)was considered to be not irritating to the rabbits’ skin.