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EC number: 253-326-2 | CAS number: 37052-78-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 October 1982 - 10 November 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,3-dihydro-5-methoxy-2H-benzimidazole-2-thione
- EC Number:
- 253-326-2
- EC Name:
- 1,3-dihydro-5-methoxy-2H-benzimidazole-2-thione
- Cas Number:
- 37052-78-1
- Molecular formula:
- C8H8N2OS
- IUPAC Name:
- 5-methoxy-1,3-dihydro-2H-benzimidazole-2-thione
Constituent 1
- Specific details on test material used for the study:
- Assay: 97%
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- On arrival at the laboratory and regularly during the acclimatisation period the rabbits were examined for signs of disability.
The animals were acclimatised to laboratory conditions for 3 weeks.
The animals were kept singly in polypropylene cages, measuring approximately 50x50 cm, each with a separate dung tray. Clean dung trays were provided-three times a week and clean cages when
considered necessary or at least every second week.
The air was changed about 15 times per hoGr via a centrally placed air intake-and two peripheral ventilators.
Target values for temperature and humidity were 17 ± 1°C and 50 ± 10%, respectively. Recorded values for temperature were within the stipulated iimits, but the relative humidity was 62 % throughout the trial.
The animal rooms were illuminated by artificial light from fluorescent tubes on a 12-hour light/dark cycle.
Each animal received approximately 150 g feed (Maintenance feed for rabbits and guinea-pigs, Ewos AB, Sweden) once daily, and also a fistful of hay, and had free access to municipal tap water for human consumption.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Amount / concentration applied:
- 0.3 g mixed with 10 drops of water.
- Duration of treatment / exposure:
- 24 h
- Observation period:
- Up to 48 h
- Number of animals:
- 3
- Details on study design:
- The back and sides of each animal were clipped free of fur, approximately 24 hours before application of the formulations.
Each test or control formulation was applied to approximately 6 cm of the intact skin of the animal, with the help of a 2.5 cm x 2.5 cm
compress. The relevant amount the formulation was spread or dripped onto the compress.
The dressing was left in place for 24 hours. Skin reaction was recorded before the formulations are applied, and directly, 1 and 24 hours after removal of the compresses. Daily observations were subsequently continued as necessary up to 14 days after removal.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Time point:
- 24 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Time point:
- 24 h
- Remarks on result:
- other: Erythema score not specifically specified
- Irritation parameter:
- edema score
- Time point:
- 24 h
- Remarks on result:
- other: edema score not specifically specified
- Irritant / corrosive response data:
- No skin reaction was seen in any animal after application of the test compound or the saline and untreated controls.
Readings were made directly, 1 hours and 24 hours after removal of the compresses, but were subsequently discontinued, due to
absence of reaction.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No signs of adverse skin reaction were seen in any animal. The test material is not a skin irritant according to this test.
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