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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Principles of method if other than guideline:
BASF-Test, see details in remarks on material and methods.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
- Name of test material (as cited in study report): 2,6-Dimethyl-morpholin (75 % cis/25 % trans)
- Physical state: liquid

Test animals

Species:
rabbit
Strain:
Vienna White

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
no
Duration of treatment / exposure:
3 min and 1 h
Observation period:
8 days
Number of animals:
2 females
Details on study design:
TEST SITE
- Area of exposure: 1x1 cm


REMOVAL OF TEST SUBSTANCE
- Washing (if done): water/Lutrol (1:1)
- Time after start of exposure: 3 min and 1 h

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Remarks:
, 3 min application
Basis:
mean
Time point:
other: 24 h - 48 h
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 8 days
Remarks on result:
other: 72 h reading is missing
Irritation parameter:
edema score
Remarks:
, 3 min application
Basis:
mean
Time point:
other: 24 h - 48 h
Score:
0
Max. score:
4
Reversibility:
other: no effects
Remarks on result:
other: 72 h reading is missing
Irritation parameter:
erythema score
Remarks:
, 1 h application
Basis:
mean
Time point:
other: 24 h - 48 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Remarks on result:
other: 72 h reading is missing
Irritation parameter:
edema score
Remarks:
, 1 h application
Basis:
mean
Time point:
other: 24 h - 48 h
Score:
2.5
Max. score:
4
Reversibility:
not fully reversible within: 8 days
Remarks on result:
other: 72 h reading is missing

Any other information on results incl. tables

Mean edema and erythema score from the 3 min and 1 h exposure after 3 min, 1 h, 24 h, 48 h and 8 days (animal1/animal2). Data for the 72 h time point was not recorded.

   3 min     1 h     24 h     48 h     8 days   
Exposure  edema  erythema  edema  erythema  edema  erythema  edema  erythema  edema  erythema
3 min exposure  0/0 1/1  -  - 0/0 1/1 0/0 1/1 0/0 0/0
1 h exposure  -  - 2/2 3/3 2/3 4/4 2/3 4/4 1/1 4/4

The original BASF grading was converted into the numerical grading according the OECD Draize system.

The application of the test substance for 3 min caused slight, reversible erythema.

The application for 1 h caused moderate to severe edema and severe erythema. After 24 h, parchment and leather-like necrosis were observed. The observed effects are considered as full thickness necrosis. Full thickness necrosis is considered to be an irreversible effect.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information