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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key study: Based on read-across approach from analogue substance P0310, the substance P-1057 is considered as not sensitising.

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Read-across from an analogue substance for which a guideline study (Klimish 1) is available.
Reason / purpose for cross-reference:
read-across source
Principles of method if other than guideline:
Read-across approach from data on an analogue substance.
Key result
Parameter:
SI
Value:
2.55
Test group / Remarks:
2.5%
Remarks on result:
other: Based on a read-across from an analogue substance.
Key result
Parameter:
SI
Value:
1.63
Test group / Remarks:
5 %
Remarks on result:
other: Based on a read-across from an analogue substance.
Key result
Parameter:
SI
Value:
2.22
Test group / Remarks:
10%
Remarks on result:
other: Based on a read-across from an analogue substance.
Key result
Parameter:
EC3
Remarks on result:
other: Based on a read-across from an analogue substance.
Remarks:
Could not be calculated since none of the tested concentrations induced S.I. greater than 3.
Interpretation of results:
GHS criteria not met
Conclusions:
Based on read-across approach from analogue substance P0310, the substance P-1057 is considered as not sensitising.
Executive summary:

Based on experimental results obtained in a study according to OECD 429 on analogue substance P0310 where the test item was not a skin sensitiser, the read-across approach is applied and the substance P-1057 is considered as not sensitising.

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Key study: Based on experimental results obtained in a study according to OECD 429 on analogue substance P0310 where the test item was not a skin sensitiser, the read-across approach is applied and the substance P-1057 is considered as not sensitising.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Based on the available information, the substance is not classified as skin sensitiser.