Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-793-9 | CAS number: 151-56-4
Endpoint summary
Administrative data
Description of key information
Repeated dose toxicity inhalation: supporting study: result from a publication leading to the conclusion that ethyleneimine produced gonadotropic, mutagenic and blastomogenic effects.
Repeated dose toxicity other routes: supporting studies: results from publications leading to the conclusion that ethyleneimine i.v. induces renal papillary necrosis and ethyleneimine s.c. produced sarcomas at site of injection, Harderian gland tumors, lung tumors and malignant hepatomas.
Key value for chemical safety assessment
Additional information
Repeated dose toxicity inhalation: supporting study: experimental result from a publication. In rats, 4 months. It is concluded that ethyleneimine produced gonadotropic, mutagenic and blastomogenic effects.
Repated dose toxicity other routes: supporting studies: experimental results from different publications. It is concluded the following:
In rats, one i.v. injection: ethyleneimine induces three types of renal cortical damage (papillary necrosis).
In mice, s.c., 48 weeks: ethyleneimine produced sarcomas at site of injection, Harderian gland tumors, lung tumors and malignant hepatomas.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
