Registration Dossier
Registration Dossier
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EC number: 204-255-0 | CAS number: 118-48-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
After percutaneous induction incrustation, partially open (caused by the intradermal induction) in addition to distinct erythema and edema could be observed in the test animals. The animals of control group 1 and 2 which were injected with olive oil DAB 9 (vehicle) exhibited incrustation, partially open (caused by the intradermal induction) in addition to distinct erythema and edema.
0/5 animals of the control group 1 showed skin findings after challenge with the test substance in olive oil and single olive oil, respectively. Skin findings after the 24 h reading were observed in 10/10 animals of the test group after challenge with the test substance (therefrom 4/10 with severe erythema) and in 6/10 animals after challenge with single olive oil (only slight erythema). After the 48 h reading, respective numbers were 10/10 (test substance) and 4/10 (olive oil).
Control group 2 that had been intended for a potential 2nd challenge was not needed, since a 2nd challenge was not necessary on the basis of the unambiguous results of the 1st challenge. Under these test conditions and following the results described above the test substance has a sensitizing effect on the skin of the guinea pig (BASF 1990).
Migrated from Short description of key information:
skin sensitisation
guinea pig, maximization test: positive (GLP, EU guideline B.6; BASF 1990)
Justification for classification or non-classification
According to the conditions of the test, the test substance has to be classified as skin sensitizer (R 43 according to 67/548/EEC and Cat. 1 according to GHS requirements, respectively). In addition, the test substance is listed in Annex VI to Regulation (EC) No. 1272/2008 and classified as skin sensitizer (Cat.1 according to GHS criteria).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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