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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
100 mg/L

Additional information

Justification for read across

Type of read across:one-to-one

Target Compound:CAS: 124729-02-6

Source Compound: CAS: 81936-32-5

Based on:
(1) chemical similarity: both compounds share a cyclohexyl-phenyl core structure and differ in alkyl chain length pattern and the fluoro substitution at the phenyl ring
(2) almost identical physicochemical parameters
(3) similar response in relevant higher TIER ecotox assays (i.e. fish long term toxicity, 28 d)

Target Compound
CAS: 1247929-02-6
Source Compound
CAS 81936-32-5
cyclohexyl phenyl core
Terminal alkyl chain at the cyclohexyl ring yes (C5)
yes (C3)
Terminal alkoxy chain at the phenyl ring
yes (C2)
yes (C1)
Liquid crystalline properties
Water solubility
30 µg/L (EU A.6)
25 µg/L (EU A.6)
> 6.5 (OECD 117, EU A.8)
> 6.5 (OECD 117, EU A.8)
Fish long term (28 d) from GLP compliant OECD TG 305 study
NOEC > 0.5 mg/L
(with HCO-40 as solubilzer)
NOEC > 0.1 mg/L
(with SPAN 20)
Fish Acute Toxicty (GLP, OECD TG 203)
(96h) LC50 > 100 mg/L (with HCO-40 as solubilzer)
(96 h) LC50 > 100 mg/L (
Daphnia Reproductive Toxicity (GLP, OECD TG 211)
no data
NOEC >  Water solubility (measured)


The Target Compound shows a data gap for Daphnia Reproductive Toxicity, however a chemical analogue provides data for this endpoint. Both the Target Compouond and the chemical show a high chemical similarity and almost identical physicochemical parameters. The response in higehr TIER ecotoxicological assays is almost identical. No effects have been observed in all assays performed up to the limit of water solubility.

Based on these finding it is justified to use the data from the chemical analogue (Daphnia Reproductive Toxicity (GLP, OECD TG 211)) to fill the data gap for the target compound.