Registration Dossier
Registration Dossier
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EC number: 603-009-3 | CAS number: 124729-02-8
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Type of read across:one-to-one
Target Compound:CAS: 124729-02-6
CCCCCC1CCC(CC1)C1=CC=C(OCC)C(F)=C1F
Source Compound: CAS: 81936-32-5
CCCC1CCC(CC1)C1=CC=C(OC)C=C1
Based on:
(1) chemical similarity: both compounds share a cyclohexyl-phenyl core structure and differ in alkyl chain length pattern and the fluoro substitution at the phenyl ring
(2) almost identical physicochemical parameters
(3) similar response in relevant higher TIER ecotox assays (i.e. fish long term toxicity, 28 d)
| Assay | Target Compound CAS: 1247929-02-6 | Source Compound CAS 81936-32-5 |
| cyclohexyl phenyl core | yes | yes |
| Terminal alkyl chain at the cyclohexyl ring | yes (C5) | yes (C3) |
| Terminal alkoxy chain at the phenyl ring | yes (C2) | yes (C1) |
| Liquid crystalline properties | yes | yes |
| Water solubility | 30 µg/L (EU A.6) | 25 µg/L (EU A.6) |
| logP | > 6.5 (OECD 117, EU A.8) | > 6.5 (OECD 117, EU A.8) |
| Fish long term (28 d) from GLP compliant OECD TG 305 study | NOEC > 0.5 mg/L (with HCO-40 as solubilzer) | NOEC > 0.1 mg/L (with SPAN 20) |
| Fish Acute Toxicty (GLP, OECD TG 203) | (96h) LC50 > 100 mg/L (with HCO-40 as solubilzer) | (96 h) LC50 > 100 mg/L ( |
| Daphnia Reproductive Toxicity (GLP, OECD TG 211) | no data | NOEC > Water solubility (measured) |
Justification
The Target Compound shows a data gap for Daphnia Reproductive Toxicity, however a chemical analogue provides data for this endpoint. Both the Target Compouond and the chemical show a high chemical similarity and almost identical physicochemical parameters. The response in higehr TIER ecotoxicological assays is almost identical. No effects have been observed in all assays performed up to the limit of water solubility.
Based on these finding it is justified to use the data from the chemical analogue (Daphnia Reproductive Toxicity (GLP, OECD TG 211)) to fill the data gap for the target compound.
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