Registration Dossier
Registration Dossier
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EC number: 603-009-3 | CAS number: 124729-02-8
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
For this endpoint information from a structural similar compound is available. This study for this similar compound was performed according to GLP and the methods applied are fully compliant with OECD TG 201.
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 130 µg/L
Additional information
Type of read across:one-to-one
Based on:
(1) chemical similarity: The surrogate (CAS: 174350-05-1) provides all main chemical features present in the dossier compound (CAS: 124729-02-6). Both substances share typical structural features for liquid crystals, i.e. one phenyl ring coupled via single bond to a cyclohexyl ring. The phenyl ring shows a fluoro substition (dossier compound: n=2, surrogate: n=2) and an ethoxy substitution in para position. The only difference in terms of chemical structure is the length of the alkyl moiety connected to the cyclohexyl ring in para position (surrogate: n=3; dossier compound: n=5).
Overall this almost perfect match results in a high chemical similarity score of 1.00 (Tanimoto).
(2) almost identical physicochemical key parameters relevant for bioavailability
| Assay | Target: 124729-02-6 | Source: 174350-05-1 |
|---|---|---|
| Phenyl cyclohexyl core | yes | yes |
| Liquid crystalline properties | yes | yes |
| Water solubility | 0,030 mg/L (EU A.6) | 0,130 mg/L (EU A.6) |
| logP | > 6,5 (OECD 117, EU A.8) | > 5.7 (OECD 117, EU A.8) |
(3) Relevant data of the source molecule
The source compound (CAS: 174350-05-1) was tested in a GLP compliant test according to OECD 202. No effects have been detected in this assay up the limit of water solubility. The NOEL of this study is larger than 100 mg/L.
(4) Conclusion
Due to the high chemical similarity and the almost identical phys-chem profile, a read across from the source compound data to fill the data gap for the endpoint of short-term toxicity to aquatic invertebrates for the target chemical is justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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