Registration Dossier
Registration Dossier
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EC number: 939-185-6 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- The justification document on the read across category approach is included in IUCLID 13.
Data source
Materials and methods
Test material
- Reference substance name:
- Benzenesulfonic acid, methyl-, C20-24 (even numbered) sec-alkyl derivs.
- EC Number:
- 939-185-6
- Molecular formula:
- C8H11(CH2)nSO3 n=19-23
- IUPAC Name:
- Benzenesulfonic acid, methyl-, C20-24 (even numbered) sec-alkyl derivs.
- Test material form:
- liquid: viscous
- Details on test material:
- Appearance: viscous opaque suspension
Constituent 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 5.33
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: mean of 1, 24, 48, 72 hrs
- Score:
- 5.25
- Max. score:
- 6
- Reversibility:
- not reversible
- Remarks on result:
- other: highly irritating
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Conclusions:
- No skin irritation/corrosion study with the target substance is available. Data generated with the category substance LABS is considered pivotal to this endpoint and this is the most conservative approach. LABS is classified as category 1C according to CLP regulation (corrosive to skin) and therefore the target substance will also be classified as category 1C. .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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