Registration Dossier
Registration Dossier
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EC number: 939-185-6 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Justification for type of information:
- The justification document on the read across category approach is included in IUCLID section 13.
Data source
Materials and methods
Test material
- Reference substance name:
- Benzenesulfonic acid, methyl-, C20-24 (even numbered) sec-alkyl derivs.
- EC Number:
- 939-185-6
- Molecular formula:
- C8H11(CH2)nSO3 n=19-23
- IUPAC Name:
- Benzenesulfonic acid, methyl-, C20-24 (even numbered) sec-alkyl derivs.
- Test material form:
- liquid: viscous
- Details on test material:
- Appearance: viscous opaque suspension
Constituent 1
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1, 24, 48, 72 hrs and 6 days
- Score:
- 46.9
- Reversibility:
- not fully reversible within: 6 days
- Remarks on result:
- other: the test substance LABS was moderately irritating but because of intensity of necrosis formation, the study was stopped at day 6. The test substance is considered corrosive
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- There is no eye irritation study available with the target substance. Data generated with the category substance LABS is considered pivotal to this endpoint and is the conservative approach. LABS is considered to be classified as category 1 (serious eye damage 1) and thus also the target substance will be classified as category 1. .
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