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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer- reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Acute oral toxicity of test chemical in rats
Author:
D. Belsito et. al.
Year:
2012
Bibliographic source:
Food and Chemical Toxicology,2012
Reference Type:
publication
Title:
Acute oral toxicity of test chemical in rats
Author:
D. L. J. Opdyke
Year:
1979
Bibliographic source:
Food and Cosmetics Toxicology,December 1979
Reference Type:
publication
Title:
Acute oral toxicity of test chemical in rats
Author:
T.B.Adams et. al.
Year:
2005
Bibliographic source:
Food and Chemical Toxicology ,2005
Reference Type:
other: authoritative database
Title:
Acute oral toxicity of test chemical in rats
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2018
Reference Type:
review article or handbook
Title:
Acute oral toxicity of test chemical in rats
Author:
World Health Organization
Year:
2003
Bibliographic source:
WHO FOOD ADDITIVES SERIES: 50,2003
Reference Type:
review article or handbook
Title:
Acute oral toxicity of test chemical in rats
Author:
Richard J. Lewis
Year:
2012
Bibliographic source:
Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set,2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute Oral toxicity test was carried out to study the effects of test chemical on rats.
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Phenethyl butyrate
EC Number:
203-119-8
EC Name:
Phenethyl butyrate
Cas Number:
103-52-6
Molecular formula:
C12H16O2
IUPAC Name:
phenethyl butyrate
Test material form:
other: Liquid
Details on test material:
- Name of test material (as cited in study report):Phenethyl butyrate
- Molecular formula:C12H16O2
- Molecular weight:192.256 g/mole
- Smiles notation: c1(CCOC(CCC)=O)ccccc1
- InChl: 1S/C12H16O2/c1-2-6-12(13)14-10-9-11-7-4-3-5-8-11/h3-5,7-8H,2,6,9-10H2,1H3
- Substance type:Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
4600 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
4 600 mg/kg bw
Based on:
test mat.
95% CL:
>= 4 200 - <= 5 000
Remarks on result:
other: 50 % mortality observed
Mortality:
50 % mortality observed in treated rats.
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be 4600 mg/kg bw (95% Confidence interval: 4200-5000),when ten rats were treated with test chemical orally.
Executive summary:

Acute oral toxicity study was performed in ten rats using test chemical at dose concentration of 4600 mg/kg bw.50% mortality was observed at dose 4600 mg/kg bw. Hence,LD50 value was considered to be 4600 mg/kg bw(95% Confidence interval: 4200-5000),when rats were treated with test chemical orally.