Registration Dossier
Registration Dossier
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EC number: 203-119-8 | CAS number: 103-52-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer- reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- D. Belsito et. al.
- Year:
- 2 012
- Bibliographic source:
- Food and Chemical Toxicology,2012
- Reference Type:
- publication
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- D. L. J. Opdyke
- Year:
- 1 979
- Bibliographic source:
- Food and Cosmetics Toxicology,December 1979
- Reference Type:
- publication
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- T.B.Adams et. al.
- Year:
- 2 005
- Bibliographic source:
- Food and Chemical Toxicology ,2005
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2018
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- World Health Organization
- Year:
- 2 003
- Bibliographic source:
- WHO FOOD ADDITIVES SERIES: 50,2003
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity of test chemical in rats
- Author:
- Richard J. Lewis
- Year:
- 2 012
- Bibliographic source:
- Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set,2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute Oral toxicity test was carried out to study the effects of test chemical on rats.
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Phenethyl butyrate
- EC Number:
- 203-119-8
- EC Name:
- Phenethyl butyrate
- Cas Number:
- 103-52-6
- Molecular formula:
- C12H16O2
- IUPAC Name:
- 2-phenylethyl butanoate
- Test material form:
- other: Liquid
- Details on test material:
- - Name of test material (as cited in study report):Phenethyl butyrate
- Molecular formula:C12H16O2
- Molecular weight:192.256 g/mole
- Smiles notation: c1(CCOC(CCC)=O)ccccc1
- InChl: 1S/C12H16O2/c1-2-6-12(13)14-10-9-11-7-4-3-5-8-11/h3-5,7-8H,2,6,9-10H2,1H3
- Substance type:Organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- 4600 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 4 600 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 4 200 - <= 5 000
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50 % mortality observed in treated rats.
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The lethal concentration (LD50) value for acute oral toxicity test was considered to be 4600 mg/kg bw (95% Confidence interval: 4200-5000),when ten rats were treated with test chemical orally.
- Executive summary:
Acute oral toxicity study was performed in ten rats using test chemical at dose concentration of 4600 mg/kg bw.50% mortality was observed at dose 4600 mg/kg bw. Hence,LD50 value was considered to be 4600 mg/kg bw(95% Confidence interval: 4200-5000),when rats were treated with test chemical orally.
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