Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The median lethal dose (LD50) was 2167  mg/kg for both sexes

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
2 000 mg/kg bw

Additional information

Isobutyrophenone was tested for acute toxicity in rats after oral administration. Mortality occurred 23 hours after treatment and on day 3 of the study.The median lethal doses(LD50),determined by logit analysis, after an observation period of 14 days, were:

- 2167 (1718 - 2732) mg/kg for males and females;

- > 2000 mg/kg for males; and

- 1946 (1734 - 2185) mg/kg for females.

Justification for classification or non-classification

There are conclusive but not sufficient data for classification of Isobutyrophenone with regard to acute oral toxicity.

Isobutyrophenone is not classified for this endpoint in accordance to Directive 67/548/EEC or the CLP Regulation (EC) No 1272/2008.