Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 944-459-3 | CAS number: -
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
EC50 (72 h, growth rate) = 11 mg a.i./L (Scenedesmus subspicatus, nominal, read-across, EU Method C.3)
NOEC (72 h, growth rate) = 3 mg a.i./L (Scenedesmus subspicatus, nominal, read-across, EU Method C.3)
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 11 mg/L
- EC10 or NOEC for freshwater algae:
- 3 mg/L
Additional information
Since no toxicity tests with algae are available for C12-14AS MIPA (CAS 85681-66-9), read-across to other structurally related category members was conducted and corroborates the findings of the study mentioned above. Read-across data from the following similar C12-14 mixtures were used: C12-14AS TEA (CAS 90583-18-9) and C12-14AS Na (CAS 85586-07-8). Toxicity of alkyl sulfates is dependent on the carbon chain length and the influence of the counter ion can be neglected.
The study investigating toxic effects of C12-14AS TEA (CAS 90583-18-9) to freshwater algae Desmodesmus subspicatus was performed according to EU Method C.3 and GLP principles (Elementis 1996). Growth inhibition caused by the test substance was determined after 24, 48 and 72 h of exposure under static conditions to seven test concentrations up to 300 mg/L as anionic active substance (nominal values in agreement with the measured values). The results show that the 72-hour EC50 value for growth rate was 11 mg a.i./L for growth rate and 9.3 mg a.i./L for biomass (nominal concentrations). The NOEC value for growth rate was determined to be 3 mg a.i./L (nominal concentration). Due to structural and property similarity with the tested category member, the 72-hour EC50 value of 11 mg/L and NOEC of 3 mg/L (both for growth rate) is considered as reliable for C12-14 MIPA (CAS 85681-66-9) for freshwater algae.
The toxicity of sulfuric acid, mono-C12-14 alkyl esters, sodium salts (CAS 85586-07-8) to aquatic algae was investigated in the GLP-compliant study with Desmodesmus subspicatus according to EU Method C.3 (Elementis 1995). Algae were exposed to six test concentrations up to 20 mg/L (nominal concentration corresponding to 17 mg/L of measured concentration). The study resulted in the 72-hour EC50 value for growth rate of above 20 mg a.i./L (nominal concentration). The EC10 (72 h) for growth rate was 5.4 mg a.i./L (nominal concentration).
Additional information about the toxicity of C12-14AS Na to algae is available from a publication by Verge and Marino 1996. The authors performed a non-GLP-study with Pseudokirchnerella subcapitata, according to OECD guideline 201. In this study the EC50 (72 h) for growth rate was determined to be 27 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
