Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 209-674-2 | CAS number: 590-19-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
1,2-Butadiene is a flammable gas at room temperature and therefore the requirement for data on acute oral and dermal toxicity is waived in accordance with REACH Annex XI. The acute inhalation LC50 of 1,2-butadiene in rats is greater than 8000 ppm (17,701 mg/m3) (the explosive limit).
Key value for chemical safety assessment
Additional information
The requirement for data on acute oral and dermal toxicity is waived in accordance with REACH Annex XI, as 1,2 -butadiene is a flammable gas at room temperature. The acute inhalation LC50 of 1,2-butadiene in rats was reported to be greater than 0.8% (v/v) (8000 ppm,17,701 mg/m3). Higher concentrations could not be tested because of the risk of explosion. Exposure to 1,2 -butadiene resulted in narcosis but no mortality or abnormal behaviour occurred in the post-exposure observation period (TNO 1980). There are no acute toxicity data on 1,2 -butadiene in humans but volunteer studies have been carried out on 1,3 -butadiene in humans. Unsteadiness was noted after exposure at 4000 ppm (8851 mg/m3) for 6 h and the odour was described as objectionable, but there was little effect at 8000 ppm (17,701 mg/m3) for 8h (Carpenter et al, 1944). 1,2 -Butadiene is concluded to have low acute toxicity.
Justification for classification or non-classification
1,2 -Butadiene is a flammable gas at room temperature and therefore inhalation exposure is the only relevant route. 1,2 -Butadiene is of low acute toxicity by the inhalation route with LC50 values exceeding the doses which would warrant classification under Dir 67/548/EEC or GHS/CLP.
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