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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Endpoint summary

Administrative data

Description of key information

Biodegradation in water

Biodegradability of 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine (CAS no. 39577 -43 -0) is predicted using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor (2017). Test substance undergoes 0.76% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 1 -(3 -chlorophenyl)-4 -(3 -chloropropyl)piperazine was estimated to be not readily biodegradable in water.

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 1 -(3 -chlorophenyl)-4 -(3 -chloropropyl)piperazine (CAS No. 39577 -43 -0). If released in to the environment, 6.01% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 1 -(3 -chlorophenyl)-4 -(3 -chloropropyl)piperazine in water is estimated to be 180 days (4320 hrs). The half-life (180 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is moderate to high whereas the half-life period of 1 -(3 -chlorophenyl)-4 -(3 -chloropropyl)piperazine in sediment is estimated to be 1620.833 days (38900 hrs). Based on this half-life value, it indicates that 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine is persistent in sediment.

Biodegradation in soil

The half-life period of 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine (CAS No. 39577-43 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 92.8% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine in soil is estimated to be 360 days (8640 hrs). Based on this half-life value of 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine, it is concluded that the chemical is persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to high.

Additional information

Biodegradation in water

Various predicted data for the target compound 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine (CAS No. 39577-43-0) and various supporting weight of evidence studies for its read across substances were reviewed for the biodegradation end point which are summarized as below:

 

In a prediction done by SSS (2017) using OECD QSAR toolbox version 3.3 with logKow as the primary descriptor, percentage biodegradability of test chemical1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine(CAS No. 39577-43-0) was estimated.Test substance undergoes 0.76% degradation by BOD in 28 days. Thus, based on percentage degradation, the test chemical 1 -(3 -chlorophenyl)-4 -(3 -chloropropyl)piperazine was estimated to be not readily biodegradable in water.

 

In another prediction using the Estimation Programs Interface Suite (EPI suite, 2017), the biodegradation potential of the test compound 1 -(3 -chlorophenyl)-4 -(3 -chloropropyl)piperazine (CAS No. 39577-43-0) in the presence of mixed populations of environmental microorganisms was estimated.The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine is expected to be not readily biodegradable.

 

In a supporting weight of evidence study from authoritative database (J-CHECK, 2017) for the read across chemical 9 -(2 -carboxyphenyl)-3,6 -bis(diethylamino) xanthenium chloride (CAS no. 81 -88 -9), biodegradation in water screening test is conducted for 4 weeks (28 days) for evaluating the biodegradability of read across substance 9 -(2 -carboxyphenyl)-3,6 -bis(diethylamino)xanthenium chloride. Concentration of inoculum i.e, sludge was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of read across substance is determined to be 0, 2 and 7% degradation by BOD, TOC removal and UV-Vis parameter in 28 days. Thus, based on percentage degradation, substance 9 -(2 -carboxyphenyl)-3,6 -bis (diethylamino)xanthenium chloride is considered to be not readily biodegradable in nature.

 

For the another read chemical 4,4'-methylenebis(N,N-dimethylaniline) (CAS no. 101-61-1), biodegradation study was conducted for 28 days for evaluating the percentage biodegradability of read across substance 4,4'-methylenebis(N,N-dimethylaniline) (J-CHECK, 2017). Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of read across substance was determined to be 0 and 1% degradation by BOD and HPLC parameter in 28 days. Thus, based on percentage degradation, 4,4'-methylenebis(N,N-dimethyl aniline) is considered to be not readily biodegradable in nature.

 

On the basis of above results for target chemical1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine(CAS No. 39577-43-0)(from OECD QSAR toolbox version 3.3 and EPI suite, 2017) and for its read across substance (from authoritative database J-CHECK, 2017), it can be concluded that the test substance 1 -(3 -chlorophenyl)-4 -(3 -chloropropyl)piperazine can be expected to be not readily biodegradable in nature.

 

Biodegradation in water and sediment

Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 1 -(3 -chlorophenyl)-4 -(3 -chloropropyl)piperazine (CAS No. 39577 -43 -0). If released in to the environment, 6.01% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of 1 -(3 -chlorophenyl)-4 -(3 -chloropropyl)piperazine in water is estimated to be 180 days (4320 hrs). The half-life (180 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is moderate to high whereas the half-life period of 1 -(3 -chlorophenyl)-4 -(3 -chloropropyl)piperazine in sediment is estimated to be 1620.833 days (38900 hrs). Based on this half-life value, it indicates that 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine is persistent in sediment.

Biodegradation in soil

The half-life period of 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine (CAS No. 39577-43 -0) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 92.8% of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine in soil is estimated to be 360 days (8640 hrs). Based on this half-life value of 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine, it is concluded that the chemical is persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to high.

On the basis of available information, the test substance 1 -(3 -chlorophenyl)-4 -(3 -chloropropyl)piperazine can be considered to be not readily biodegradable in nature.