Registration Dossier
Registration Dossier
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EC number: 202-261-8 | CAS number: 93-60-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from International Programme on Chemical Safety
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Safety evaluation of certain food additives
- Author:
- Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Year:
- 2 006
- Bibliographic source:
- International Programme on Chemical Safety World Health Organization (IPCS), WHO FOOD ADDITIVES SERIES: 54, 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity of Methyl nicotinate in mice
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Methyl nicotinate
- EC Number:
- 202-261-8
- EC Name:
- Methyl nicotinate
- Cas Number:
- 93-60-7
- Molecular formula:
- C7H7NO2
- IUPAC Name:
- methyl pyridine-3-carboxylate
- Test material form:
- solid
- Details on test material:
- - Name of test material (as cited in study report): Methyl nicotinate
- Molecular formula (if other than submission substance): C7H7NO2
- Molecular weight (if other than submission substance): 137.137 g/mol
- Substance type: Organic
- Physical state: white solid powder
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Methyl nicotinate
- Molecular formula (if other than submission substance): C7H7NO2
- Molecular weight (if other than submission substance): 137.137 g/mol
- Substance type: Organic
- Physical state: white solid powder
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available.
- Doses:
- 2800 mg/kg bw
- No. of animals per sex per dose:
- No data available.
- Control animals:
- not specified
- Details on study design:
- No data available.
- Statistics:
- No data available.
Results and discussion
- Preliminary study:
- No data available.
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 800 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50 % mortality observed
- Mortality:
- 50 % mortality was observed in rats at 2800 mg/kg bw
- Clinical signs:
- other: No data available.
- Gross pathology:
- No data available.
- Other findings:
- No data available.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- LD50 was considered to be 2800 mg/kg bw when mice were treated with Methyl nicotinate orally.
- Executive summary:
In acute oral toxicity study, mice were treated with Methyl nicotinate orally in the concentration of 2800 mg/kg bw. 50 % mortality was observed in rats at 2800 mg/kg bw. Therefore, LD50 was considered to be 2800 mg/kg bw when mice were treated with Methyl nicotinate orally.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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