Registration Dossier
Registration Dossier
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EC number: 221-717-7 | CAS number: 3209-22-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
- Principles of method if other than guideline:
- Acute dermal toxicity in rats
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,2-dichloro-3-nitrobenzene
- EC Number:
- 221-717-7
- EC Name:
- 1,2-dichloro-3-nitrobenzene
- Cas Number:
- 3209-22-1
- Molecular formula:
- C6H3Cl2NO2
- IUPAC Name:
- 1,2-dichloro-3-nitrobenzene
- Details on test material:
- - Analytical purity: No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Age at study initiation: ca. 14 weeks
- Weight at study initiation: 179 g
- Housing: 5 animals per cage (Macrolon type III)
- Diet (e.g. ad libitum): Altromin R 1324 (Altromin GmbH, Lage, Germany) ad libitum
- Water (e.g. ad libitum): tap-water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 1.5
- Humidity (%): 60 +/- 5
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- polyethylene glycol
- Duration of exposure:
- not specified
- Doses:
- 2500 mg/kg bw
- No. of animals per sex per dose:
- 10 males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animals were observed for clinical signs and mortality several times on the day of administration, and twice daily thereafter (once on weekends and holidays) up to the end of the observation period. Animals were weighed on the day of admisitration and at hte end of the 14-days observation period.
- Necropsy of survivors performed: no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no mortality, no clinical signs were observed
- Mortality:
- no effects
- Clinical signs:
- other: no effects
- Gross pathology:
- not examined
Any other information on results incl. tables
No signs of toxicity were observed in all male animals treated with 2500 mg/kg bw. No mortalities occurred.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
The test material was dissolved in Lutrol (polyethylene glycol) at 0.5 g/ml and applied to the skin of 10 male animals. No signs of toxicity were observed in all male animals treated with 2500 mg/kg bw. No mortalities occurred.
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