Registration Dossier

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
September 1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Open Epicutaneous Test
Version / remarks:
Testing method only, no guideline available.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl oct-2-ynoate
EC Number:
203-836-6
EC Name:
Methyl oct-2-ynoate
Cas Number:
111-12-6
Molecular formula:
C9H14O2
IUPAC Name:
methyl oct-2-ynoate
Test material form:
liquid

Test animals

Species:
guinea pig
Strain:
not specified

Test system

Type of coverage:
open
Preparation of test site:
clipped
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
Undiluted and then in concentrations of 30, 10 3 and 1% or lower in ethanol, acetone, water, vaseline, PEG and /or other suitable vehicles
Duration of treatment / exposure:
During of study: 21 days
Applications of test materials were repeated daily for 3 weeks or done 5-times weekly during 4 weeks.
Observation period:
24 hours after each aplication or at the end of each week.
Number of animals:
6-8 guinea pigs per concentration group.

Results and discussion

In vivo

Results
Irritation parameter:
erythema score
Basis:
mean
Time point:
24 h
Reversibility:
not specified
Remarks on result:
other: Slight irritation observed
Remarks:
A "slight" response was observed at 100% after 7 days.

Any other information on results incl. tables

Single application of 3% alcoholic solution of FOLIONE is well tolerated, when applied repeatedly very slight skin irritation occurs in the third week of treatment.

Applicant's summary and conclusion

Interpretation of results:
Category 3 (mild irritant) based on GHS criteria
Executive summary:

Folione is considered to be a mild skin irritant and is classified under the GHS criteria as SCI3.