Registration Dossier
Registration Dossier
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EC number: 203-836-6 | CAS number: 111-12-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Open Epicutaneous Test
- Version / remarks:
- Testing method only, no guideline available.
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl oct-2-ynoate
- EC Number:
- 203-836-6
- EC Name:
- Methyl oct-2-ynoate
- Cas Number:
- 111-12-6
- Molecular formula:
- C9H14O2
- IUPAC Name:
- methyl oct-2-ynoate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
Test system
- Type of coverage:
- open
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- Undiluted and then in concentrations of 30, 10 3 and 1% or lower in ethanol, acetone, water, vaseline, PEG and /or other suitable vehicles
- Duration of treatment / exposure:
- During of study: 21 days
Applications of test materials were repeated daily for 3 weeks or done 5-times weekly during 4 weeks. - Observation period:
- 24 hours after each aplication or at the end of each week.
- Number of animals:
- 6-8 guinea pigs per concentration group.
Results and discussion
In vivo
Results
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- other: Slight irritation observed
- Remarks:
- A "slight" response was observed at 100% after 7 days.
Any other information on results incl. tables
Single application of 3% alcoholic solution of FOLIONE is well tolerated, when applied repeatedly very slight skin irritation occurs in the third week of treatment.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
- Executive summary:
Folione is considered to be a mild skin irritant and is classified under the GHS criteria as SCI3.
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