Registration Dossier
Registration Dossier
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EC number: 203-462-3 | CAS number: 107-10-8
Endpoint summary
Administrative data
Description of key information
Irritation:
- skin: corrosive
- eye: corrosive
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
In a primary skin irritation study n-propylamine caused surface dermatolysis in three out of six animals. Subsequently these sites became dry, hard, and concave. This reaction is characteristic of dry necrosis (Pennwalt 1977; reliability score: 2). Corrosive to highly irritating effects to skin were found in a second study (Smyth et al. 1962; reliability score: 2).
In a primary eye irritation study corrosive effects (corneal opacity) could be observed (Pennwalt 1977; reliability score 2). A further publication confirmed these results (Smyth et al.1962; reliability score: 2).
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Skin
Due to the effects seen in two older but valid studies, n-propylamine is considered as corrosive to the skin.
Eye
Due to the reported corneal injury of the rabbit eye in two studies, n-propylamine is considered as corrosive.
EU classification according to Annex VI of Directive 67/548/EEC: C, R34
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